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While the evidence is still not enough to warrant the clinical use of sildenafil (or any other PDE5i) for the treatment of diabetic heart kinetics or as a first-line treatment for other CV complications in such patients, this new avenue of research looks promising, and new trials will hopefully allow the drafting of guidelines for clinical practice

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In these cases, pharmacists should be ready to recommend alternative drugs to the prescribing physician

Cholesteryl ester storage disease: a most unusual manifestation of deficiency of two lysosomal enzyme activities

Nutrients (2021) 13(9):3126

doi: 10.1080/10408398.2016.1158148