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In addition to this feature exploited in achieving a high-density immobilization of bioreceptors, nanobiosensors benefit from the unique NP properties to enhance biological signaling and transduction mechanisms since these nanostructures catalyze the bioreactions, mediate the electron transfer, amplify the mass change, and refine the refractive index changes [599,608,609]

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J Biol Chem 283:3318333190