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Cell lines and culture The HT29, HCT116, SW480, and LoVo cells were purchased from the ATCC and the RKO cell was a gift from Dr

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Oroboros oxygraph data were generated in DatLab (version 8.0, Oroboros Instruments) and exported to Microsoft Excel where the average peak difference in oxygen consumption was calculated

Key TJ, Bradbury KE, Perez-Cornago A, Sinha R, Tsilidis KK, Tsugane S

CBD can modulate the redox state both directly, by acting on components of the redox system, and indirectly, through interactions with molecular targets associated with this system (Sabbag et al., 2025)

A perfect example of the drawbacks of scientific paradigms

Non-Selective Multi-Receptor Action Pigmentation (MC1R): Activation of MC1R on melanocytes stimulates melanogenesis and the production of protective eumelanin, leading to skin darkening (tanning) without extensive UV exposure