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Activation of NF-kB/Rel proteins therefore requires degradation of IkB proteins via ubiquitin-mediated proteolysis to initiate nuclear translocation and DNA binding of active NF-kB/Rel complexes [84]

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This inhibition is associated with a reduction in mitochondrial membrane potential, suppression of ATP synthesis, and oxidation of endogenous NAD(P)H and protein thiol groups

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