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For comparison between two groups, an independent-sample t -test was used, with Levenes test applied to assess variance homogeneity

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Schoen et al., 2014), resulting in differences within the meningococcal population that may impact virulence

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Gaps in safety assessment encompass limited long-term data in vulnerable populations, an incomplete understanding of horizontal gene transfer related to antimicrobial resistance, and uncertainty regarding the systemic impact of prolonged microbiome modulation, particularly with next-generation strains lacking a long history of safe use (142)