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Consequently, oxidative stress occurs, and when it becomes excessive, it can lead to muscle damage

Damage to the intestinal barrier entails a number of adverse phenomena: dysbiosis, translocation of microorganisms deep into the intestinal tissue, immune response, development of chronic inflammation

There are 497 human genes that encode a cofactor-dependent enzyme, of which at least 193 (39%) reportedly harbor disease-causing variants [69, 70] (Additional file 8 : Table S6)

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It acts as a mast cell stabilizer, reducing the release of histamine and other inflammatory compounds