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Riferimenti: Pyo et al

Several lines of evidence suggested TNF role in enhancing the mitochondrial ROS generation triggering through calcium-dependent pathways [75]

During the clinical trial, the treatment group received four overall doses (1 per 13 weeks) of the hMSC infusions, with about 100 million allogeneic hUC-MSCs dispensed intravenously

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Phosphoseryl-tRNA (PSTK) PSTK is in charge of the phosphorilation of the precursor Serine located on the specific tRNAsec [10]

In addition, due to the advantage of small size (approximately 14 nm), GSH-CDs could be more readily absorbed and thus more efficiently function as ROS scavengers in the confined microenvironment of the intervertebral disc without exerting excessive pressure on the disc tissue