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In vivo Toxicity Test Female Balb/c mice, aged 68 weeks and weighing 1820 g, were randomly divided into four groups: the PBS group, BUD group, LNPs group, and BUD-LNPs group, each comprising three mice

In guinea pigs, the administration of curcumin and encapsulated DEX prior to treatment effectively mitigated the ototoxic effects of cisplatin, thereby safeguarding auditory function across all frequencies

Polyunsaturated fatty acids (PUFA), one of the main components of the lipid membrane, react with OH and 1 O 2 to form conjugated dienes, hydroperoxy, lipid peroxy radicals, and dienes [206]

Although laboratory alterations are seen, such as a reduction in serum T 4 by 25%, T 3 by 15% and a 2 mU/L rise in TSH, these values remain within the normal ranges without clinical signs of thyroid dysfunction (32)

Shortly, one might consider using combination therapy

This suggests that the response to surface thickness may be partially mediated by cellular stiffness-sensing mechanisms 141