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10.1016/j.cell.2007.06.049 Cell 11 LeeA

However, it should be noted that excessive vitamin B6 (pyridoxine) ingestion in the form of vitamin B16-12 combination tablets may also cause irreversible neurotoxicity (171)

It can, but the evidence is weaker than the label-dose weight-loss evidence

Rab18 collaborates with Rab7 to modulate lysosomal and autophagy activities in the nervous system: an overlapping mechanism for Warburg Micro Syndrome and Charcot-Marie-Tooth neuropathy type 2B