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LPS binding to TLR4 triggers intracellular signaling cascades, including the release of NO and TNF- , activation of ERK/STAT pathways, and engagement of the canonical NF-B/MAPK pathways

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Furthermore, during ischemiareperfusion, excessive activation of the sympathetic nervous system leads to autonomic nervous system imbalance [7], increased cardiac oxygen consumption, and oxygen supplydemand imbalance, further exacerbating myocardial damage

Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells