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Obese human and animal models are generally accompanied with abnormal circulating IGF-1 levels [130], as well as IGF-1/IGFBP-3 ratio

A significant increase in the ventricle time interval was observed after incubation in 10 nM of CuSO 4 , while no significant change was observed if the CuSO 4 was cotreated with a GHK peptide at every concentration (Figure 4B)