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Other organ systems, such as the digestive and cardiovascular systems, also contain peripheral nerves, so CIPN can also lead to symptoms such as swallowing problems, constipation, and heart arrhythmias (Burgess 2021)

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Fluorescence images were captured on a LSM510META laser scanning microscope (Zeiss, Germany)

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It is believed that most TPs, possibly over 80%, remain in the gut where they are metabolized into short-chain fatty acids and phenolic acids by esterases and glucosidases produced by the gut microbiota (116), thereby enhancing the bodys capacity to break down and utilize these polyphenols, increasing the proportion of active substances involved in metabolic regulation (116)