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The two-domain methyltransferase/corrinoid-binding CmuA protein catalyzes methyl transfer from CM to a cobalt-corrin cofactor (Studer et al., 2001), and the methylcobalamin:tetrahydrofolate methyltransferase CmuB transfers the resulting corrinoid-bound methyl group to tetrahydrofolate (H 4 F) (Studer et al., 1999)

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