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In a number of studies of patients with MDD, evidence has been found of increased neuroinflammatory markers associated with lower levels of antioxidants (Morris et al

Hwang, P., Morales Marroqun, F

Thus, while the idea that chronic excitotoxicity contributes to multiple neurodegenerative diseases is supported by many layers of scientific evidence, it is not clear that therapeutic interventions that re-establish glutamatergic homeostasis during ongoing neurodegeneration will be effective tools for stopping the disease process

Moreover, the combination of novel drugs with existing treatment modalities (e.g., SGLT2 inhibitors with ferroptosis inhibitors, antioxidants like selenocysteine with Ferrostatin-1 or Liproxstatin-1, and GLP-1 receptor agonists with ferroptosis inhibitors) (207209) will be an important area of future research

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In particular, pro-apoptotic Noxa is dispensable for normal erythropoiesis