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However, with the recognition of apoptosis and its detailed signaling mechanisms, reports were published suggesting that APAP also triggers apoptotic cell death [40, 41]

Due to the often severe neurological symptoms of mitochondrial disease patients, primary care and research often focus on the characterization and management of the neuromuscular manifestations, while the numerous and comparatively secondary metabolic complications remain neglected

J Exp Biol 196:263281 Blakely RD, Ramamoorthy S, Schroeter S, Qian Y, Apparsundaram S, Galli A, DeFelice LJ (1998) Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins

Many studies have shown that they have high application value in DM and cardiovascular diseases ( Mangiferin, a compound derived from mangoes, possesses various pharmacological and nutritional properties

However, LCA had no effect on the activation and proliferation of CD4+ T cells in vitro , which was caused by the low expression of TGR5 in T cells

A., Pereira, M