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Surveys across various regions in China among adults aged 1865 years show an annual prevalence of headache as 28.5%, with most cases being primary migraines frequently seen in middle-aged women (Yu et al., 2013, 2012, 2011)

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The VSAC are a family of membrane proteins that mediate the passive transport of organic anions in response to changes in intracellular osmolarity (Jackson and Strange, Another mechanism that has been proposed as transporter is an ascorbate-glutamate hetero-exchange (Grnewald and Fillenz, Tissue distribution The organs with the highest concentration of ascorbate are the adrenal glands (550 mg/kg), the brain (140 mg/kg), the liver (125 mg/kg), and in terms of size, the skeletal muscle with a concentration of 35 mg/kg (Richelle et al., In order for ascorbate to be able to reach tissues, it must go through the endothelial barrier of each tissue

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