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PMID 12728264

Astaxanthin ameliorated parvalbumin-positive neuron deficits and Alzheimers disease-related pathological progression in the hippocampus of App(NL-G-F/NL-G-F) Mice

NaHS treatment elevated the ubiquitination level of Kelch-like ECH-associated protein (Keap1) by preserving its E3 ligase synoviolin (Syvn1), resulting in Nrf2 nuclear translocation

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Consistent intake of approximately 200 mg/day through diet and supplements is crucial for sustaining adequate VIC levels, ensuring overall health improvement, and reducing the risk of deficiency-related complications [12,17,18]

This is further supported by the study of Yang, Huang (102) in which the significant induction of cytokines, chemokines, and adhesion molecules (such as TNF-, IL-1, MCP-1, CXCL1, ICAM-1, VCAM-1) in human brain microvascular endothelial cells by SARS-CoV-2, suggesting an activation of the vascular endothelium in the brain