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Combination strategies further enhance therapeutic efficacy: pairing metabolic inhibitors with chemotherapy (such as PKM2 inhibitors combined with 5-FU), immunotherapy (including IDO1 inhibitors used in conjunction with anti-PD-L1 agents), or radiotherapy (for example, SCD1 inhibitors administered alongside ferroptosis inducers) can synergistically amplify anti-tumor effects

For example, ferroptosis sensitivity can be increased by overexpression of TfR, which enhances iron uptake, and by decreased expression of FTH1 and FTL, which lowers ferritin levels and thereby reduces iron storage [25]

Wagner, University of Giessen, Germany Updates Copyright 2023 Sahoo, Heilmann, Paital, Patel, Yadav, Wong and Jergens

Intercellular distribution of glutathione synthesis in maize leaves and its response to short-term chilling

Inflammatory bowel disease (IBD) is a term for two conditions (Crohns disease and Ulcerative Colitis) that are characterized by chronic inflammation of the gastrointestinal (GI) tract

The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer