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Research has indicated that compounds targeting TRP channels, such as vanillin, capsaicin and capsazepine, can reduce reactive astrocyte activity, which in turn can mitigate A toxicity in the early stages of AD 154

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Due to the formation of intramolecular hydrogen bonds between the -COO- group and -OH group in the ortho position in 2,3-DHBA, the 2,3- and 3,4-DHBA molecules behave somewhat differently in aqueous solution, which is reflected in their speciation behavior [1]

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