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doi: 10.1016/j.lfs.2023.122037 [DOI] [PubMed] [Google Scholar] 43

Converging mechanisms in ALS and FTD: Disrupted RNA and protein homeostasis

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From a chemical perspective, this smart switching capability originates from dynamic changes in microenvironmental cues, such as nanozyme concentration, H 2 O 2 levels, and pH, which alter the dominant enzymatic activity, thereby achieving dual-mode ROS regulation by toggling between antioxidative and pro-oxidative states