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CHEW Director Writes 'Data Drives Health and Wellness' Stephanie Adamec, director of the Center for Health, Education and Wellness (CHEW), wrote an article for Connections, the AJCU newsletter

Jul 23 2021;61(1):140-153

Saturation mutagenesis was performed on S586

5.6 What has actually worked in PC nanomedicine and why (and what failed) Despite thousands of preclinical studies and significant investments in the clinical translation of nanomedicines for PC, only two nanoformulations, namely nanoparticle albumin-bound paclitaxel (nab-paclitaxel, Abraxane ) and nanoliposomal irinotecan (Onivyde ), have been approved by the FDA and EMA for the treatment of pancreatic cancer (PC) (124,181)

XL880 has been tested in Phase II clinical trials in metastatic gastric cancer, papillary renal cell carcinoma and head and neck squamous cell cancer ( MP470 is a multi-kinase inhibitor, orally available, that was reported to radiosensitizeglioblastoma cell lines, through the suppression of RAD51, a DNA repair related protein (Welsh et al., 2009)