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J., Barber T

Blackwell Science

However, sustained high levels of calcium overload lead to the opening of the mPTP, mitochondrial swelling, and rupture of the outer mitochondrial membrane (OMM)

Neurology (Parkinsons disease) Intranasal GSH: A phase I, single-group pilot in Parkinsons disease demonstrated acute CNS uptake by MRS after intranasal administration, establishing feasibility but not clinical efficacy

injection and by the yolk-sac method

Abbreviations AAP: American Academy of Paediatrics AD: Autoimmune disease ADHD: Attention deficit/hyperactivity disorder APA: American Psychiatric Association ARE: Arylesterase ASD: Autism spectrum disorders CNS: Central nervous system CSF: Cerebrospinal fluid DSM: Diagnostic and statistical manual of mental disorders EEG: Electroencephalogram GST: Glutathione S-Transferase ICD: International classification of diseases IFN: Interferon IL: Interleukin MIA: Maternal immune activation NHIS: National Health Interview Survey PON-1: Paraoxonase-1 PUFA: Polyunsaturated fatty acid NOS: Nitric oxide synthase OSI: Oxidative stress index RCT: Randomized clinical trial ROS: Reactive oxygen species TAS: Total antioxidant status TNF: Tumour necrosis factor TOS: Total oxidant status XO: Xanthine oxidase References Di Lorenzo R, Balducci J, Poppi C, Arcolin E, Cutino A, Ferri P, et al