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Recently, a study of genome-wide lncRNA expression in the lung tissue of nonsmokers ( n = 5) and smokers with ( n = 5) or without ( n = 5) COPD showed that, in smokers without COPD, 87 lncRNAs were significantly upregulated and 244 were downregulated compared to the lncRNAs expressed in the nonsmokers [97]

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