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Without this tightly timed degradation, repression within the TTFL would resolve too quickly, leading to shortened circadian cycles or arrhythmicity

Int J Mol Sci (2021) 22:6531

Biochemistry 50(47): 10408-10417

10.1007/s10571-022-01200-z Cell

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Finally, differences in the selection of detection indicators (total bilirubin, direct bilirubin, or indirect bilirubin), sample size, study design (cross-sectional or longitudinal), and the relationship between sample collection time and the onset of the disease further increase the complexity of cross-study comparisons