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For instance, in HCC and GBM, activation of multiple pathways, such as NF-B and STAT3 promotes LCN2 transcription and expression, leading to reduced intracellular iron levels and diminished lipid peroxidation

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

Taken together, various histone modifications have been shown to exert an essential regulatory effect on metabolic reprogramming in cancer cells, thereby increasing or decreasing tumor progression

349 The intensity of the regulatory link between epigenetic modification and transcription may vary in different developmental stages and cell types, adding a layer of complexity and uncertainty in delineating the specific spatiotemporal transcriptional regulation