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31 Detoxification Dysfunction The role of xenobiotic metabolizing enzymes (XMEs) in the disease etiology of PD has been under investigation by numerous researchers for the last two decades

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In mammalian cells AA (C20, 4) is one of the most abundant polyenoic fatty acids (FAs) that serve as substrates for the different mammalian LOXs [33], after oxidized by 15LOX, 12LOX and 5LOX, the HOO-group at the 15th, 12th or 5th carbon of the arachidonoyl residue generates 15/12/5-HpETE-phosphatidylethanolamine, respectively (Fig