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Biomarker discoveryincluding epigenetic regulators and microbiome-derived signalsmay enable earlier diagnosis and personalization

23,49 This severe dysbiosis leads to the collapse of gut barrier function, allowing bacteria and their products (such as LPS and ammonia) to translocate to the portal vein and systemic circulation, directly driving the occurrence of fatal complications such as HE and spontaneous bacterial peritonitis (SBP)