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The impact of iron deposition on the fear circuit of the brain in patients with Parkinsons disease and anxiety

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Concurrently, in an MPTP-induced PD model, QCT was administered at 60 mg/kg daily for 8 days, activating the Nrf2/GPX4/SLC7A11 signaling pathway, which improved motor function and preserved dopaminergic neurons (Lin et al., 2022)

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Current studies increasingly suggest that these signaling perturbations interact through immunevascularmetabolic pathways to disrupt cell-to-cell communication, feedback regulation, and structural stability at the maternalfetal interface, thereby potentially impairing implantation or placental perfusion (43)

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