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This loss of TDMD was attributable to reduced polyubiquitylation, as indicated by biochemical assays (Extended Data Fig

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There are data demonstrating the involvement of the CD95-L/CD95 system in drug-induced death of cancer cells and suggesting a contributory role of the alterations of the function of this system in the occurrence of drug resistance [66]

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In addition, the further pharmacological, electrophysiological, and molecular genetic approaches also confirm that GLRs participate in the establishment of root architecture in Arabidopsis by interaction with Ca 2+ , mitogen activated protein kinase (MAPK), ROS, and auxin (Lpez-Bucio et al., 2019)