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Front Microbiol 8: 01205

Various analgesic mechanisms induced by curcumin effectively attenuate pain by modulating pain-related neurotransmitters by modulating the immune response or blocking transient receptor potential vanilloid type I (TRPV1), as well as modulating purinergic receptors and chemokines, which has been shown in animal and human studies (Lim et al., 2013

Interestingly, our study showed that Sert inhibited haemorrhagic transformation through downregulation of neuronal CD163 expression, attenuation of MMP-2, MMP-9 levels and HO-2 activity