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The interplay between liver clocks and skeletal muscle clocks plays an important role in supporting systemic glucose tolerance [46]

Disclosures: Deeksha Kartik: Nothing to Disclose, Lara Murray: Nothing to Disclose, Jacqueline Brosnan-Cashman: PathAI: Employee, PathAI: Stock privately held company, Neel Patel: PathAI: Employee, Ylaine Gerardin: PathAI: Employee, Robert Egger: Nothing to Disclose, Adam Stanford-Moore: Nothing to Disclose 826 SIMPLE NONINVASIVE TESTS HAVE POOR DIAGNOSTIC ACCURACY FOR MASLD F2-3 IN A REAL WORLD CANADIAN COHORT Nashla Hamdan 1 Chinmay Bera 2 Heather Kosick 1 Keyur Patel 1 , 1 University of Toronto, 2 Toronto General Hospital Background: Several Non-invasive test (NIT) that have been proposed to identify patients with advanced fibrosis (F3-4) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD)

According to this simultaneous modulation (SREBP-1c, LXR), exercise and cinnamon improve hepatic metabolism by directing it away from lipid storage and toward better lipid clearance and cholesterol management

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[55] and Yamazaki et al