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[5] Through gene regulation, estradiol promotes vaginal epithelial maturation, supports collagen synthesis within skin, and contributes to nitric-oxide-mediated vasodilation, collectively providing mechanistic explanations for clinical benefits such as improved vulvovaginal comfort and reduction in hot-flash frequency

Its key to taking steps to prevent it

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The PRISMA statement for reporting systematic and metaanalyses of studies that evaluate interventions: explanation and elaboration

Ongoing oxidative stress is linked to many chronic diseases (1) including cancer, cardiovascular disease, diabetes, osteoarthritis, and dementia

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