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Proteotoxicity: an underappreciated pathology in cardiac disease

The manifestation of these systemic therapy-related side effects is highly individualised, influenced by factors such as patient age, menopausal status, and the presence of comorbidities, including hypertension [13, 14]

Prez de la Lastra et al., 2021

Curcumin inhibits the primary nucleation of amyloid-beta peptide: a molecular dynamics study

Arch Biochem Biophys 713:109061

Curcumin showed a protective antioxidant effect against gentamycin-induced oxidative stress documented by alleviated lipid peroxides, increased levels of superoxide dismutase and glutathione, increased expression of Bcl-2, a protein protecting against oxidative stress, suppressed proapoptotic Bax, and suppressed executioner caspase in apoptosis, caspase-3