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Introduction Metabolomic studies have identified numerous circulating metabolites that correspond to an enhanced risk of cardiovascular disease (CVD) ( LCACs accumulate intracellularly and embed within membrane compartments of the ischemic myocardium ( LCAC Biogenesis and Cardiovascular Disease Associations A detailed description of LCAC biogenesis is beyond the scope of this review and has been done previously (Figure 1)

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Blood 115 , 47424749 (2010)

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