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(2022) have explored that the -elemene integrated with erlotinib enhanced the cytotoxicity of erlotinib against EGFR mutated primary EGFR-TKI resistant NSCLC cells, and diminished the content of ferroptosis negative regulatory proteins (glutaminase, FTH1, Nrf2, Slc7a11 and GPX4), added ROS and lipid peroxidation levels, and accomplished anti-tumor effects through ferroptosis

Kai D, Liow SS, Loh XJ

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In addition to the disease process being associated with a breach in the intestinal barrier functions, patients with hematologic and oncologic diseases are particularly at high risks for the development of increased intestinal permeability, due to the frequent use of broad-spectrum antibiotics and chemoradiation

doi: 10.1186/1741-7015-11-119 Pubmed Abstract CrossRef Google Scholar View reference in article 13 KesslerRCAngermeyerMAnthonyJCDE GraafRDemyttenaereKGasquetIet al