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Further studies incorporating stereological analysis and assessment of interstitial volume, edema, or Leydig cell morphology are warranted to clarify the biological significance of this observation

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Auslander, Leora and Tara Zahra (2018) Introduction

Administration of a bolus, usually a drink, containing large neutral amino acids (LNAA), but lacking tryptophan, limits the transport of endogenous tryptophan across the blood-brain barrier through competition with other LNAAs undergoing active transport