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Acknowledgments Authors would like to extend their sincere gratitude to the Deanship of Scientific Research at King Saud University, Riyadh, Saudi Arabia for funding the work through the research group project No

Increased expression of SPARC mediates some of the exercise-induced benefits both in terms of metabolic functions, including enhancement of glucose usage and oxidative phosphorylation, as well as tissue remodeling [35]

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The breakdown process of BCAAs is similar in all species, initially forming branched-chain -keto acids (BCKAs) via branched-chain amino acid transferase (BCATs) and transferring nitrogen to nitrogen receptors (the most common nitrogen receptor is -ketoglutaric acid (-KG) to form glutamate)