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Moreover, APAP-induced mitochondrial damage has been shown to partly result from the suppression of PPAR-regulated pathways, leading to irreversible inhibition of fatty acid oxidation

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MRI scans were performed using a T1w volumetric fast spoiled gradient echo (FSPGR) sequence (slice thickness = 1.5 mm, repetition time = 33.33 ms, echo time = 6 ms, flip angle = 35)