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provided evidence that the interplay between the signals of mechanistic target of rapamycin kinase (mTOR) and GPX4 modulates autophagydependent ferroptosis in human pancreatic cancer cells, and the downregulated expression of GPX4 enhances the anti-cancer activity of rapamycin in vitro or in vivo by promoting ferroptosis and suppressing autophagy [38]

This effect is similar to that observed in our published study with early pancreatic cancer

doi: 10.1089/thy.2017.0395 78 ZhaoH.YuanL.ZhuD.SunB.DuJ.WangJ

Furthermore, environmental particulate matter has the ability to cross the blood-brain barrier and penetrate the nasal mucosa epithelium, activating the nervous system by binding to particular receptors and producing oxidative stress (Lucchini et al., 2012)

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