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Under oxidative stress these three systems work in concert to detoxify ROS and lipid peroxides, maintain protein structure and function via thiol repair, prevent activation of redox-sensitive inflammatory pathways, and preserve mitochondrial membrane integrity and prevent apoptosis

J Neurosci (1992) 12:210411

To this end, many drugs have been repurposed, including tocilizumab, sarilumab, heparin, chloroquine, ivermectin, sarilumab, chromones ( Most of the effort has been so far devoted to the identification of medications capable to revert the worst and life-threatening complications of COVID-19, namely cytokine storm and hypercoagulation ( This crucial phase of the malady, in analogy with other viral infections and to a widely accepted pharmacological praxis, should be timely treated either with etiotropic drugs (which in COVID-19 case are still lacking) as well as with host-directed agents to manage/prevent the symptoms ( NSAIDs, Paracetamol, and COVID-19 In March 2020, ibuprofen and NSAIDs were discouraged because of the alert by Micallef et al

Circ Res 131:e120e134 Felizardo RJF, de Almeida DC, Pereira RL, Watanabe IKM, Doimo NTS, Ribeiro WR, Cenedeze MA, Hiyane MI, Amano MT, Braga TT et al (2019) Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms

Consistent, daily dosing of Vitamin D3 is increasingly favored in clinical practice over massive, infrequent boluses, as it provides a more stable regulation of immunomodulatory hormones

As a potent antioxidant, it performs several vital functions: Detoxification: It helps neutralize harmful toxins and free radicals, supporting liver health and natural cleansing processes