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This impairs cellular functions and further exacerbates mitochondrial dysfunction [58]

It activated the Nrf-2/ARE signaling pathway, this subsequently decreased the elevated production of ROS and MDA, enhanced the expression of SOD and GSH, and ultimately resulted in a reduction of oxidative stress levels

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Polymorphisms of MRP1 (ABCC1) and related ATP-dependent drug transporters

Induction of tumor regression by intratumoural STING agonists combined with antiprogrammed deathL1 blocking antibody in a preclinical squamous cell carcinoma model

After internalisation, when pH increases above 6.5, the amino groups of chitosan become positively charged and chitosan precipitates, inducing increased intracellular drug accumulation