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In guinea pig spinal cord homogenate-induced experimental autoimmune encephalomyelitis (EAE) in rats, chronic caffeine reduces disease incidence, attenuates clinical severity, and decreases inflammatory infiltration and demyelination during both peak and recovery phases [59]

397 In addition, these metabolic disorders have a complicated internal relation, for instance, T2DM and NAFLD are independent factors for each other, and PCOS is closely related to insulin resistance and T2DM

As expected for enzymes that share the same co-substrate, some of the residues contributing to the recognition of GSH, Ser92 and Asp172, are conserved

GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47)

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