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SARS-CoV2 Nsp3 protein triggers cell death and exacerbates amyloid 42-mediated neurodegeneration

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An in vivo assessment revealed relatively higher glutamine anaplerosis into the TCA cycle in malignant BM plasma cells as compared to pre-malignant plasma cells (56)

Similar to the observation made after the knockdown of ALK5 , the protection by the treatment with SM16 was specific to aSyn-overexpressing cells (Fig