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Klotho plays a crucial role in modulating FGF23 signaling and its effects on target tissues, primarily the kidneys (109)

For instance, GSH can be depleted, through inhibition of its synthesis using an inhibitor of GCL (buthionine sulfoximine, BSO) (57) under conditions that maintain the intracellular cysteine pool intact,

Thus, the correct folding of most of the proteins translocated into the periplasm and beyond in the model bacterium Escherichia coli depends on the formation of native disulfide bonds

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