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Gupta, G

These changes result in an overall amplification of intracellular estrogen bioavailability and support a mechanism by which local concentrations of estrogen can change quickly following acute stress or damage (Pomari et al., 2015)

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The pathological hallmark of AD is the deposition of amyloid plaques and neurofibrillary tangles in the gray matter due to aberrant processing of amyloid precursor protein (APP) leading to the aggregation of amyloid- (A) peptides and tau protein, respectively