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Ssu72 regulates adipose tissue remodeling through GSK3 signaling To elucidate the underlying molecular mechanism of Ssu72 function, we investigated expression profiles of representative marker molecules involved in adipogenic signaling pathways using eWAT from HFD-fed WT and aKO mice (Fig

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) to form peroxynitrite (ONOO - ) with a rate constant that is larger than that for the SOD-catalyzed dismutation of ( Following NO/ONOO - exposure, significant effects on cellular GSH metabolism are reported

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GGCT channels Gln flux for GSH synthesis and Glc anaplerosis into the TCA cycle ROS act as signaling molecules that regulate mitochondrial function, with mitochondrial morphology intrinsically linked to core processes, including the TCA cycle and oxidative phosphorylation