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Small sample sizes, absent control groups, and publication bias mean these results could overestimate true effects

Reported biochemical potency against human NNMT is in the low-micromolar range with cellular EC values in the low-micromolar range for suppression of 1-MNA and lipogenesis, with selectivity over related methyltransferases and NAD-salvage enzymes [1,6,7]

doi: 10.1038/s41467-020-19249-z

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For it to be a success, there need to be world records, he said