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The interaction between oral and gut microbiota can influence the brain through the gut-brain axis, including disturbances in neurotransmitter metabolism, activation of systemic immune responses, and direct or indirect effects of bacterial metabolites (such as short-chain fatty acids, lipopolysaccharides, etc.) on the bloodbrain barrier and neural function

Further elucidation of the mitochondrial quality control pathways used to protect cells may provide potential opportunities for PD treatment in cases of mitochondrial dysfunction (Figure 1)

Milk thistle may help protect liver cells from medication-related oxidative damage and support normal liver function in such cases

Tlaskalov-Hogenov H, Stpnkov R, Kozkov H et al (2011) The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases

B12 may help dementia since there may be a consequential link to low blood levels

While other aspects of the tumor microenvironment are likely to impact radiation response, such as hypoxia and neuroanatomical location, molecular profiling may provide significant insight to support individualized radiotherapy planning