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Nakhaee, S

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Room temperature storage accelerates degradation significantly

Taken together, in children with nephrotic syndrome IGF-1 levels are decreased and high-affinity IGFBPs (mainly IGFBP-1/-2) are markedly increased, resulting in an excess of unsaturated IGFBPs which may inhibit IGF action on target tissues by enhanced IGF-binding and/or competition with the IGF-1R