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1 Supporting Data The approval for dato-DXd was supported by findings from 2 clinical trials: the Efficacy was evaluated in a pooled subgroup analysis of the TROPION-Lung05 and TROPION-Lung01 trials composed of 114 patients with locally advanced/metastatic EGFR -mutated NSCLC who had received prior EGFR-directed therapy and platinum-based chemotherapy

Meanwhile, 5-Amino-1MQ helps inhibit an enzyme called NNMT, which normally diverts NAD+ precursors away from energy production pathways

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An enzyme called NNMT (nicotinamide N-methyltransferase) drains the NAD+ salvage pathway by methylating nicotinamide, one of NAD+'s precursors